An offender has fled the scene of a botched ram raid at a cycling store with their arm on fire after the business erupted into flames.

Mystery culprits used a stolen car to ram the garage door of a business in Melbourne's inner north suburb of Brunswick about 2.55am on Tuesday, police said.

It is believed the offenders used the black BMW X5 to ram the door two or three times, before jumping out of the vehicle and entering the store.

Police remain on the scene. (Source: Nine)

The ramming then led to a fire inside the business.

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It was reported to police that one of the offenders was spotted fleeing the scene with one of their arms on fire.

The stolen vehicle was left behind and the offenders were last seen running off.

The fire caused significant damage to the building and it remains unclear if anything was stolen from the store.